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Featured article: AD-LIBS: inferring ancestry across hybrid genomes using low-coverage sequence data

Flickr CC 2.0 Arend Vermazeren https://creativecommons.org/licenses/by/2.0/legalcode

This study by Schaefer et al. presents 'AD-LIBS'; a tool that effectively infers ancestry. It can be used when a few individuals are available for comparison, and can be used without requiring variant calling or phasing. The authors apply the tool to datasets for European genomes with Neanderthal ancestry and brown bear genomes with polar bear ancestry. While the ancestry maps relating to human genome agree with published results and global ancestry rates, it was determined for brown bears that there is more polar bear ancestry than was previously reported. AD-LIBS is therefore likely to be useful in studies of non-model or ancient organisms that lack large amounts of genomic DNA and can expand the range of studies in which admixture mapping is a viable tool.

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