Genomics|Update|Current: Ebola: Genomics & Public Health

Genomics|Update|Current

Ebola: Genomics & Public Health

CDC information: Outbreak of Ebola in Guinea, Liberia, and Sierra Leone

CDC Information: Ebola hemorrhagic fever is a severe, often fatal disease in humans and nonhuman primates

Genome sequences filoviruses, including Ebola virus,are available and indexed on NCBI-genome 

Phylogenetic analysis of Guinea 2014 EBOV Ebolavirus outbreak, 
Gytis Dudas et al.  PLOS Pathogens Outbreaks, April 2014

CDC Article: Whole-genome expression profiling reveals that inhibition of host innate immune response pathways by Ebola virus can be reversed by a single amino acid change in the VP35 protein.
Hartman AL, Ling L, Nichol ST, Hibberd ML. J Virol. 2008 Jun;82(11):5348-58.

Tackling Ebola: new insights into prophylactic and therapeutic intervention strategies
Emmie de Wit et al. Genome Medicine (2011).

HSPA5 is an essential host factor for Ebola virus infection.
Patrick Reid S, et al. Antiviral Res. 2014 Jul 11. 

Biomarker correlates of survival in pediatric patients with Ebola virus disease
McElroy AK, et al. Emerg Infect Dis, Oct 2014.

CDC article: Sequence-based human leukocyte antigen—B typing of patients infected with Ebola virus in Uganda in 2000: identification of alleles associated with fatal and nonfatal disease outcomes
Sanchez A, et al. J Infect Dis 2007; 196(S2): S329-S336.

Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection
Wauquier N, et al. Immunogenet 2010; 62(11-12):767-771.