Outcomes of Radiation, Surgery, or Observation for Localized Prostate Cancer | Oncology | JAMA | The JAMA Network

Outcomes of Radiation, Surgery, or Observation for Localized Prostate Cancer | Oncology | JAMA | The JAMA Network

Prostate Cancer Surgery More Likely Than Other Treatments To Result in Decreased Sexual Function After 3 Years

Removal of the prostate gland and surrounding tissue – radical prostatectomy – was more likely to result in decreased sexual functioning than either external beam radiation therapy (EBRT) or active surveillance/watchful waiting in patients with prostate cancer, according to AHRQ-supported research that examined outcomes in the three years following treatment. The analysis of 2,550 men also showed that radical prostatectomy was associated with significant declines in urinary incontinence compared with EBRT and active surveillance. The article, "Association Between Radiation Therapy, Surgery, or Observation for Localized Prostate Cancer and Patient Reported Outcomes After 3 Years," appeared online today in JAMA. Researchers said findings will help clinicians counsel patients about the comparative benefits and harms of prostate cancer treatments. Access the abstract.

March 21, 2017

Association Between Radiation Therapy, Surgery, or Observation for Localized Prostate Cancer and Patient-Reported Outcomes After 3 Years

Daniel A. Barocas, MD, MPH¹; JoAnn Alvarez, MA²; Matthew J. Resnick, MD, MPH¹; et alTatsuki Koyama, PhD²; Karen E. Hoffman, MD, MHSc, MPH³; Mark D. Tyson, MD¹; Ralph Conwill, BS⁴; Dan McCollum, BS⁴; Matthew R. Cooperberg, MD, MPH⁵; Michael Goodman, MD, MPH⁶; Sheldon Greenfield, MD⁷; Ann S. Hamilton, PhD, MA⁸; Mia Hashibe, PhD, MPH⁹; Sherrie H. Kaplan, PhD, MS, MPH¹⁰; Lisa E. Paddock, PhD, MPH¹¹; Antoinette M. Stroup, PhD¹¹; Xiao-Cheng Wu, MD, MPH¹²; David F. Penson, MD, MPH^1,13

Author Affiliations

JAMA. 2017;317(11):1126-1140. doi:10.1001/jama.2017.1704