domingo, 7 de septiembre de 2014

PLOS Genetics: Human Social Genomics

PLOS Genetics: Human Social Genomics

Human Social Genomics

  • Steven W. Cole mail
  • Published: August 28, 2014
  • DOI: 10.1371/journal.pgen.1004601

A growing literature in human social genomics has begun to analyze how everyday life circumstances influence human gene expression. Social-environmental conditions such as urbanity, low socioeconomic status, social isolation, social threat, and low or unstable social status have been found to associate with differential expression of hundreds of gene transcripts in leukocytes and diseased tissues such as metastatic cancers. In leukocytes, diverse types of social adversity evoke a common conserved transcriptional response to adversity (CTRA) characterized by increased expression of proinflammatory genes and decreased expression of genes involved in innate antiviral responses and antibody synthesis. Mechanistic analyses have mapped the neural “social signal transduction” pathways that stimulate CTRA gene expression in response to social threat and may contribute to social gradients in health. Research has also begun to analyze the functional genomics of optimal health and thriving. Two emerging opportunities now stand to revolutionize our understanding of the everyday life of the human genome: network genomics analyses examining how systems-level capabilities emerge from groups of individual socially sensitive genomes and near-real-time transcriptional biofeedback to empirically optimize individual well-being in the context of the unique genetic, geographic, historical, developmental, and social contexts that jointly shape the transcriptional realization of our innate human genomic potential for thriving.

Reviews, News & Commentaries

stacked papers
Human social genomics.External Web Site Icon 
Steven W. Cole, PLOS Genetics, August 28, 2014
Practical aspects of genome-wide association interaction analysisExternal Web Site Icon 
Gusareva ES & Van Steen K Hum Genet 2014 Aug
What is big data?External Web Site Icon By Jenna Dutcher, datascience at berkeley, Sep 3
Empowering patients via clinical genome sequencing,External Web Site Icon by Philippa Brice, PHG Foundation, Sept 1
Common epigenomic fingerprint found in multiple cancers,External Web Site Icon by Kevin Mayer, GEN News Highlights, Aug 26

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