Smoking
Smoking and Health: Public Health and Genomic Insights - July 17, 2015
CDC and Related Info
- E-cigarette use triples among middle and high school students in just one year
- 58 million nonsmokers in US are still exposed to secondhand smoke
- Secondhand smoke exposure is harmful and remains high for certain groups
- CDC's Tips from former smokers campaign provided outstanding return on investment
- More than 16 million children live in states where they can buy e-cigarettes legally
- CDC blog post (2012):Smokescreen: What's genomics got to do with smoking?
- Genes reported in relation to smoking, including genomewide association studies via theHuGE Navigator
Sociodemographic and psychological characteristics of very light smoking among women in emerging adulthood, national survey of drug use and health, 2011
X Li et al, Prev Chronic Dis, July 2015
X Li et al, Prev Chronic Dis, July 2015
Correlation of smoking-associated DNA methylation changes in buccal cells with DNA methylation changes in epithelial cancer.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Teschendorff AE et al. JAMA Oncol 2015 Jul 1. (4) 476-485
Teschendorff AE et al. JAMA Oncol 2015 Jul 1. (4) 476-485
Screening strategies and primary prevention interventions in relatives of people with coronary artery disease: A systematic review and meta-analysis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Goldfarb M et al. Can J Cardiol 2015 May (5) 649-57
Goldfarb M et al. Can J Cardiol 2015 May (5) 649-57
Death toll from cigarettes much higher than previously estimated,
by AE Cha, Washington Post, June 16
Deaths due to cigarette smoking for 12 smoking-related cancers in the United States.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Siegel RL et al. JAMA Intern Med 2015 Jun 15.
Siegel RL et al. JAMA Intern Med 2015 Jun 15.
World No Tobacco Day - May 31, 2015
MMWR, May 29, 2015
MMWR, May 29, 2015
Lack of associations of CHRNA5-A3-B4 genetic variants with smoking cessation treatment outcomes in Caucasian smokers despite associations with baseline smoking.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Tyndale RF et al. PLoS ONE 2015 (5) e0128109
Tyndale RF et al. PLoS ONE 2015 (5) e0128109
Genetic ancestry as an effect modifier of naltrexone in smoking cessation among African Americans: an analysis of a randomized controlled trial.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Bress A et al. Pharmacogenet. Genomics 2015 Jun (6) 305-12
Bress A et al. Pharmacogenet. Genomics 2015 Jun (6) 305-12
The association of rs1051730 genotype on adherence to and consumption of prescribed nicotine replacement therapy dose during a smoking cessation attempt.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Ware JJ et al. Drug Alcohol Depend 2015 Jun 1. 236-40
Ware JJ et al. Drug Alcohol Depend 2015 Jun 1. 236-40
Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Wang G et al. PLoS ONE 2015 (4) e0120824
Wang G et al. PLoS ONE 2015 (4) e0120824
Lack of association between DRD2 Taq1A gene polymorphism and smoking cessation therapy: a meta-analysis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Choi HD et al. Int J Clin Pharmacol Ther 2015 Apr 17.
Choi HD et al. Int J Clin Pharmacol Ther 2015 Apr 17.
CHRNA5 risk variant predicts delayed smoking cessation and earlier lung cancer diagnosis-a meta-analysis.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Chen Li-S et al. J. Natl. Cancer Inst. 2015 May (5)
Chen Li-S et al. J. Natl. Cancer Inst. 2015 May (5)
Are genetic variants for tobacco smoking associated with cannabis involvement?![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Agrawal A et al. Drug Alcohol Depend 2015 May 1. 183-7
Agrawal A et al. Drug Alcohol Depend 2015 May 1. 183-7
Pharmacogenetics of nicotine and associated smoking behaviors.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Tanner Julie-A et al. Curr Top Behav Neurosci 2015 37-86
Tanner Julie-A et al. Curr Top Behav Neurosci 2015 37-86
Smoking: More Public Health and Genomic Insights - April 23, 2015
CDC Newsroom: 58 million nonsmokers in US are still exposed to secondhand smoke
Two of every five children -- including seven in 10 black children -- are exposed, February 2015
Two of every five children -- including seven in 10 black children -- are exposed, February 2015
Smoking's toll on health is even worse than previously thought, a study finds,
by Denise Grady, New York Times, Feb 11
Smoking and mortality--beyond established causes.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Carter Brian D et al. N. Engl. J. Med. 2015 Feb 12. (7) 631-40
Carter Brian D et al. N. Engl. J. Med. 2015 Feb 12. (7) 631-40
Genome-wide association study of nicotine dependence in american populations: identification of novel risk Loci in both African-Americans and European-Americans.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Gelernter Joel et al. Biol. Psychiatry 2015 Mar 1. (5) 493-503
Gelernter Joel et al. Biol. Psychiatry 2015 Mar 1. (5) 493-503
Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Taylor Amy E et al. PLoS Genet. 2014 Dec (12) e1004799
Taylor Amy E et al. PLoS Genet. 2014 Dec (12) e1004799
Interaction between passive smoking and two HLA genes with regard to multiple sclerosis risk.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Hedström Anna Karin et al. Int J Epidemiol 2014 Dec (6) 1791-8
Hedström Anna Karin et al. Int J Epidemiol 2014 Dec (6) 1791-8
Interaction of intercellular adhesion molecule 1 (ICAM1) polymorphisms and environmental tobacco smoke on childhood asthma.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Li Yu-Fen et al. Int J Environ Res Public Health 2014 Jun (6) 6504-16
Li Yu-Fen et al. Int J Environ Res Public Health 2014 Jun (6) 6504-16
Pharmacogenetics of nicotine and associated smoking behaviors.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Tanner Julie-Anne et al. Curr Top Behav Neurosci 2015 37-86
Tanner Julie-Anne et al. Curr Top Behav Neurosci 2015 37-86
Polygenic score × intervention moderation: An application of discrete-time survival analysis to modeling the timing of first tobacco use among urban youth.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Musci Rashelle J et al. Dev. Psychopathol. 2015 Feb (1) 111-22
Musci Rashelle J et al. Dev. Psychopathol. 2015 Feb (1) 111-22
Smoking Cessation: Genetic Influences on Nicotine Metabolism - January 20, 2015
Patch or pills? How quickly smokers metabolize nicotine may point to most effective way to quit,
Science Daily, Jan 11
Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo-controlled trial![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Caryn Lerman, et al. Lancet Respiratory Medicine, January 2015
Caryn Lerman, et al. Lancet Respiratory Medicine, January 2015
Smoking Cessation: Tips, E-Cigarettes and Genomics - December 18, 2014
CDC information: CDC's Tips from former smokers campaign provided outstanding return on investment. National mass media anti-smoking campaign exceptionally cost-effective
Commentary: Even more illness caused by smoking than previously estimated
Steven A. Schroeder, JAMA Internal Medicine, December 2014
Steven A. Schroeder, JAMA Internal Medicine, December 2014
Recent Genomic Insights
Smokers' beliefs about the tobacco control potential of "a gene for smoking": a focus group study.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Waters EA, et al. BMC Public Health. 2014 Nov 25;14:1218
Waters EA, et al. BMC Public Health. 2014 Nov 25;14:1218
Investigating the possible causal association of smoking with depression and anxiety using Mendelian randomisation meta-analysis: the CARTA consortium.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Taylor AE, BMJ Open. 2014 Oct 7;4(10):e006141.
Taylor AE, BMJ Open. 2014 Oct 7;4(10):e006141.
Smoking behaviour: investigation of the coaction of environmental and genetic risk factors.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Treutlein J, et al. Psychiatr Genet. 2014 Dec;24(6):279-80
Treutlein J, et al. Psychiatr Genet. 2014 Dec;24(6):279-80
Novel genetic variants modify the effect of smoking on carotid plaque burden in Hispanics.![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
Della-Morte D, et al. J Neurol Sci. 2014 Sep 15;344(1-2):27-31
Della-Morte D, et al. J Neurol Sci. 2014 Sep 15;344(1-2):27-31
Smoking Cessation: Public Health and Genetic Insights - October 22, 2014
Increases in smoking cessation interventions after a feedback and improvement initiative using electronic health records — 19 community health centers, New York City, October 2010–March 2012
Sheryl L. Silfen, et al. MMWR 2014;63:921-4
Sheryl L. Silfen, et al. MMWR 2014;63:921-4
The genetic architecture of smoking and smoking cessation
dbGaP Study Accession: phs000404.v1.p1 This study includes samples from two projects:
dbGaP Study Accession: phs000404.v1.p1 This study includes samples from two projects:
Genomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment.
Chen LS, Bierut LJ. J Food Drug Anal. 2013 Dec;21(4):S87-S90.
Chen LS, Bierut LJ. J Food Drug Anal. 2013 Dec;21(4):S87-S90.
Interplay of genetic risk (CHRNA5) and environmental risk (partner smoking) on cigarette smoking reduction.
Chen LS, et al. Drug Alcohol Depend. 2014 Oct 1;143:36-43.
Chen LS, et al. Drug Alcohol Depend. 2014 Oct 1;143:36-43.
Impact of genetic notification on smoking cessation: Systematic review and pooled-analysis.
Sylviane de Viron et al. PLOS One, 2012
Sylviane de Viron et al. PLOS One, 2012
CHRNA5 variant predicts smoking cessation in patients with acute myocardial infarction.
Chen LS, et al. Nicotine Tob Res. 2014 Sep;16(9):1224-31
Chen LS, et al. Nicotine Tob Res. 2014 Sep;16(9):1224-31
Environmental and genomic factors influencing smoking cessation: A systematic review of reviews and a proposed working model![External Web Site Icon External Web Site Icon](https://lh3.googleusercontent.com/blogger_img_proxy/AEn0k_v3cIWXmdKNZcprEpZcaRt3r76_tygEW3QcbjbyD96VNB-BWM-jt6903EobvLmlakeCVbdPZqCtYhroAj5NPxafr5LZh4Iv84T2UT3ZbfaaCDhYoJeNeqjC=s0-d)
de Viron S et al. Public Health Genomics (2013)
de Viron S et al. Public Health Genomics (2013)
CDC blog post (2012): Smokescreen: What's genomics got to do with smoking?
Find out about genetic conditions and tests associated with smoking
from the NIH Genetic Testing Registry
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