domingo, 28 de agosto de 2011

Effect of Foodborne Diseases, Greece | CDC EID

Volume 17, Number 9–September 2011


Risk-based Estimate of Effect of Foodborne Diseases on Public Health, Greece

Elissavet Gkogka, Comments to Author Martine W. Reij, Arie H. Havelaar, Marcel H. Zwietering, and Leon G.M. Gorris
Author affiliations: Wageningen University, Wageningen, the Netherlands (E. Gkogka, M.W. Reij, M.H. Zwietering, L.G.M. Gorris); Utrecht University, Utrecht, the Netherlands (A.H. Havelaar); National Institute for Public Health and the Environment, Bilthoven, the Netherlands (A.H. Havelaar); and Unilever Research and Development, Shanghai, People's Republic of China (L.G.M. Gorris)
Suggested citation for this article
The public health effects of illness caused by foodborne pathogens in Greece during 1996–2006 was quantified by using publicly available surveillance data, hospital statistics, and literature. Results were expressed as the incidence of different disease outcomes and as disability-adjusted life years (DALY), a health indicator combining illness and death estimates into a single metric. It has been estimated that each year ≈370,000 illnesses/million inhabitants are likely caused because of eating contaminated food; 900 of these illnesses are severe and 3 fatal, corresponding to 896 DALY/million inhabitants. Ill-defined intestinal infections accounted for the greatest part of reported cases and 27% of the DALY. Brucellosis, echinococcosis, salmonellosis, and toxoplasmosis were found to be the most common known causes of foodborne illnesses, being responsible for 70% of the DALY. Overall, the DALY metric provided a quantitative perspective on the impact of foodborne illness that may be useful for prioritizing food safety management targets.
To initiate and sustain efforts for prevention and control of foodborne diseases, it is essential to determine the extent and dimensions of the problem (1). Accurate knowledge of disease incidence and severity is invaluable to competent national authorities for use in selecting appropriate management actions to reduce the overall public health impact. However, much of the information collated regarding foodborne illnesses by different systems cannot be directly translated into policy (2) for 3 main reasons. First, not all cases are reported to health authorities, and estimates of underreporting result in considerable uncertainty in burden of illness studies, which limits the interpretation and analysis of available information (3,4). Second, often only a fraction of illnesses caused by food-related pathogens are actually foodborne because transmission can also be through the environment, direct contact with animals, or from person to person (5). Third, foodborne illnesses may vary not only in their incidence but also in their severity, resulting in widely different clinical manifestations and potentially involving long-term sequelae, although for their accurate description and quantification a uniform health measure would be needed (6).
To circumvent the latter issue, the World Health Organization (WHO) recommends using disability-adjusted life years (DALY) as a metric to express the public health effects of foodborne diseases (2), and DALY is increasingly used for a wide variety of illnesses (6–8). The aim of this study was to test the feasibility of using publicly available relevant data sources combined with the DALY metric to quantify the annual impact of foodborne illnesses in a country in a format useful for policy decisions. The country selected was Greece. The study used available surveillance data, hospital statistics from 1996 through 2006, and literature. In an attempt to address the first 2 limitations of the types of study mentioned above, we account in our estimates for uncertainty caused by underreporting and food attribution by using probability distributions to describe a range of plausible values for these parameters. Results are also expressed as cases in the general population, reported or estimated severe cases, and deaths to enable comparisons with similar studies in other countries.


Figure 1
Figure 1.
Figure 1. Working scheme for estimating the incidence and effects of foodborne illness in Greece...
Figure 2
Figure 2.
Figure 2. Disability-adjusted life years (DALY) caused by different foodborne diseases per million inhabitants in the course of an average year in Greece, including uncertainty...
Figure 3
Figure 3.
Figure 3. Trends for the top 5 contributors to the burden of foodborne diseases in Greece, 1996–2006. DALY, disability-adjusted life years.
The various steps taken to estimate the incidence and impact of foodborne illness in Greece are shown in Figure 1. Reported cases of illnesses that may be transmitted through food were for the larger part collected from the Hellenic Statistical Authority (ELSTAT) (9) and the Hellenic Center for Infectious Diseases Control (HCIDC) (10). A limited number of data were obtained from WHO disease surveillance reports where HCIDC was mentioned to be the source (11,12) for better transparency and from other literature when no other information was available (13). The study included the period 1996–2006 for which data were available from both national sources. ELSTAT collects information regarding hospitalizations for case-patients who have a duration of stay >1 day based on the Basic Tabulation List (BTL) of the International Classification of Diseases, 9th Revision. ELSTAT data are based on sampling of hospitalized patients' bulletins.
This sampling includes bulletins of deceased patients, although these bulletins are not recorded separately. Hospitalizations recorded by the ELSTAT are likely to vary in their severity because the population in Greece had free access to hospital centers where it was possible to be treated even for minor health issues (14). HCIDC collects information on notified cases from hospital microbiologic laboratories and district health authorities (11) and also performs active surveillance on the general incidence of gastroenteritis through physicians' reports (10). HCIDC data can thus be representative of hospitalizations or visits to physicians and are a mixture of laboratory-confirmed and symptom-based notified cases. In the absence of a study validating these 2 systems of collecting information on disease incidence, we considered ELSTAT and HCIDC data to be representative of reported (severe) cases of illness. Corrections for undernotification or overnotification were not made because this would require a country-specific study that is not currently available. For the few illnesses for which data were available from both systems, ELSTAT data were preferred. For cryptosporidiosis, giardiasis, and toxoplasmosis, cases were estimated indirectly taking into account studies on prevalence of these parasites in the general population (15,16). The mean and standard deviation of reported and estimated cases for 1996–2006 were used to create normal distributions, which were considered representative of the annual incidence of these illnesses (17).
Deciding on a precise estimate of the proportion of cases that can be attributed to food is complicated (5). Because of differences in food production, consumption, and the ecology of pathogens, the percentage of foodborne transmission is expected to vary among countries and constitutes a major area of uncertainty. To make an adjustment for food attribution, PERT distributions were used as multipliers (18) (Table 1). Minimum and maximum parameters of PERT distributions were based on a literature search covering the range of potential values. Most likely values were based on data most relevant to Greece and Europe because endemicity of illnesses is often related to specific regions (19,20).
Not all cases of foodborne illness are reported to health authorities (3), and the degree of underreporting varies greatly among diseases between countries or within 1 country in different periods (21). To make an adjustment for underreporting, PERT distributions were used as multipliers (18) and extremes were selected to cover the full range of values found in literature. Most likely values were set at the middle of this range to give equal weight to extremes of each distribution (Table 1). We assumed that underreporting factors primarily represent underreported cases for serious illnesses that result in physician visits, and underreporting factors for gastrointestinal illnesses are primarily associated with cases not resulting in physician visits. Although in some studies an arbitrarily assigned factor is used to cover for misdiagnosed or undiagnosed hospitalizations and deaths (3,18), it was omitted in the absence of specific data for Greece and underreported cases caused by this phenomenon were considered to be included in the "ill-defined intestinal infections" BTL code as suggested by other authors (17). We also assumed that all reported cases were diagnosed and coded correctly.
DALY values were calculated as DALY = YLL + YLD, where YLL are the years of life lost because of premature death in the population and YLD are the years lived with disability for incident cases of the health condition (22). YLD was estimated for reported or estimated cases and underreported cases, and YLL was estimated based only on reported or estimated cases. The rationale for this was that fatal cases contributing to YLL occur at the top of the surveillance pyramid and, if diagnosed, most likely are notified, particularly for obligatory notifiable diseases such as most of the ones examined here. Moreover, for illnesses contributing to YLD such as gastrointestinal illnesses, underreported cases not resulting in hospitalization are not expected to have fatal outcomes. The sole exception was listeriosis, in DALY values mainly accounted for through YLL (23), because it has been under surveillance only since 2004. Thus, even serious cases of this infection were expected to be considerably undernotified in part of the period under study because physicians and laboratories might not immediately be aware of the new reporting requirements. Therefore, to avoid underestimation of deaths, YLD for listeriosis was estimated on the basis of reported and underreported cases.
The individual components of the DALY formula are estimated as follows: YLL = d × e, where d is the number of deaths and e is the expected individual life span at the age of death in years; YLD = n × t × w, where n is the number of cases of a specific illness, t is its duration in years and w is a weight factor (disability weight) that reflects its severity on a scale from 0 (perfect health) to 1 (death) (22,24). In calculating YLL, the number of deaths (d) was estimated by multiplying reported or estimated cases caused by foodborne infection for each illness with a PERT distribution describing a plausible range of pathogen-specific case-fatality rates (18) on the basis of literature data from other industrialized countries (Table 1). Selected case-fatality rates were always from the same level of the surveillance pyramid as reported for estimated cases. For some generic BTL codes (e.g., "Other helminthiases," "Intestinal infections due to other specified microorganism," and "Ill-defined intestinal infections"), the number of deaths was based on data from the WHO Mortality Database (25).
Regarding the expected individual life span at the age of death in years (e), the age of death was estimated on the basis of data collected by the HCIDC and ELSTAT on patients' age in reported cases. When no explicit information was available in these sources, which was the case for 5 illnesses, age at time of death was assumed to be 40 years. To check the impact of this assumption on the ranking of foodborne risks, we tested both extremes by assuming 0 years as the age at death and by assuming YLL to be 0. For "Other helminthiases," data from the WHO Mortality Database were used. General life expectancy was based on the life table for Greece for 2000 (22). For comparison, estimates were also made by using the WHO standard West Level 26 life table (22).
In calculating YLD, duration of illness (t) was based on data collected by ELSTAT and on literature regarding serious and mild forms of each cause of illness. Different disability weights (w) were used for each disease based on the severity of its sequelae and whether estimated cases likely reach the health system or not (Table 2). All underreported cases were assumed to be mild or self-limiting for gastroenteritis-related illnesses. For serious, non–self-limiting diseases such as brucellosis or echinococcosis that are not related to gastroenteritis, nonreported cases were considered to be as severe as reported or estimated cases.
All estimations were performed by using the @RISK 5.7 software (Palisade Corporation, Ithaca, NY, USA) as an add-in in Microsoft Excel 2010 (Microsoft, Redmond, WA, USA). Full details regarding estimations of DALY, selection of input distributions and simulation settings can be found in the Technical Appendix [PDF image 478 KB, 38 pages].


Annual Incidence of Foodborne Illnesses

For 1996–2006, we estimated 369,305 (95% credible interval [CrI] 68,283–910,608) illnesses per million inhabitants per year attributable to eating contaminated food, at least 905 of which (95% CrI 499–1,340) are reported or estimated to be severe and 3 fatal (95% CrI 2.0–4.8) (Table 3). Ill-defined intestinal infections accounted for most (94%) cases (sum of reported/estimated and underreported cases). Regarding reported/estimated cases, ill-defined intestinal infections were responsible again for the greatest part (72%), followed by salmonellosis (8.2%), brucellosis (7.1%), food poisoning (4.0%), and echinococcosis (2.7%). Most deaths (48%) were estimated to be caused by brucellosis, although salmonellosis, echinococcosis, listeriosis, and toxoplasmosis also contributed substantially to deaths.

Public Health Impact of Foodborne Illnesses Expressed as DALY

Foodborne illnesses accounted for ≈896 DALY per 1 million inhabitants annually (95% CrI 470–1,461), of which 14% were attributable to YLL and 86% to YLD (Table 4). As much as 34% of the estimated effects of foodborne disease in Greece could be attributed to gastroenteritis-related illnesses, and the remaining 66% was unevenly split among 6 non–gastroenteritis-related illnesses (brucellosis, echinococcosis, toxoplasmosis, leptospirosis, hepatitis A, and botulism). Notwithstanding attendant uncertainty (Figure 2), the most serious foodborne illness in Greece was brucellosis, representing ≈55% of the estimated DALY and contributing greatly to illness (>88%). Ill-defined intestinal infections were the second most serious contributor to disease burden (≈27% of DALY), followed by echinococcosis (7.8%) and salmonellosis (4.6%) as known causes of illness.


The DALY metric provided a different view on the effects of foodborne illnesses on public health in comparison to incidence estimates (Table 5). Although salmonellosis was captured as a major contributor by all 4 rankings, there was variation regarding other causes of illness. Interestingly, diseases that have the highest effect on public health either in terms of illness (ill-defined intestinal infections), death (toxoplasmosis) or both (brucellosis) are not identified in the ranking based on a single individual incidence parameter, but they are captured by DALY, which has the advantage of enabling comparisons between different disease endpoints. For instance, although toxoplasmosis is not among the 5 major contributors on the basis of the total incidence or on reported/estimated cases, it is given more prominence through using the DALY metric because this also accounts for severe outcomes and sequelae of this disease. Although self-limiting diseases may appear to be essential in terms of incidence, on the basis of DALY they do not greatly contribute to either illness or death. Therefore, use of the DALY metric gives a different and risk-based perspective of the influence of foodborne illnesses on the health of a country's population because it is estimated on the basis of the diseases' frequency (incidence) and severity (health effect).
Most of the foodborne illness cases in Greece were caused by ill-defined intestinal infections (Table 3). This finding is consistent with results from similar studies in other countries (3,17). Using the current Greek surveillance system, we cannot attribute this burden to known causes of gastroenteritis other than the ones included in this study. Noroviruses could be the etiologic agents in a large proportion of these ill-defined intestinal infections because they have been considered the most likely agent of foodborne illness caused by unknown agents (26) and have been found in other studies to be a most common cause of foodborne illness due to known agents (17,18). Outbreak data found for these pathogens were scarce (27) and therefore not included in this study. A considerable part of this category might also have been caused by other unknown agents of illness or known agents that have been misdiagnosed. For instance, campylobacteriosis is expected to be undiagnosed to a great extent in Greece because few laboratories in the country have the ability to identify the pathogen (10). This finding could partially explain the high underreporting factor estimated for this illness for Greece, based on the approach of Ekdahl and Giesecke (28) compared with results for other Western countries (3,29).
Brucellosis was found to be the leading cause of illness and death in Greece. Although its incidence showed a reasonably consistent decline during the period of this study, it still constitutes a serious public health problem (Figure 3). The disease is most common in rural areas of the country, and risk factors for its contraction are occupational contact with animals and the consumption of unpasteurized milk and milk products (30,31).
Echinococcosis was the second most notable foodborne illness. This disease has been recognized as a serious health problem in the country (32) and linked with contaminated food (10,33). Echinococcosis caused by Echinococcus granulosus (cystic echinococcosis) is the dominant form in Greece (32), where the infection is hyperendemic (19). Although its incidence has gradually decreased since 1984 as a result of a long anti-echinococcosis campaign and general improvements in living and hygiene standards (32), it still is a serious health risk for the population (Figure 3).
Salmonellosis was the third most serious foodborne illness of known etiology in terms of public health impact, and it also was the most prominent gastroenteritis-related illness of identified cause (Table 3). This finding is consistent with it being a noteworthy zoonosis, which contributes to a high prevalence of gastrointestinal illness in the European Union (34), and the most often reported causative agent of outbreaks of an identified etiologic agent worldwide (35).
After salmonellosis, congenital toxoplasmosis was also a major contributor to the disease burden, although in terms of incidence it is an uncommon illness with <4 cases per million inhabitants. The disease has not been recognized as a major foodborne illness in the country, although its serious health consequences have been well documented (36).
There are 4 major factors that add to the uncertainty in our estimates that are not independent: 1) underreporting, 2) food attribution, 3) the quality of incidence data, and 4) value choices in the DALY formula. Given the limited data available for Greece, data from other countries have been used to create multipliers for underreporting and foodborne transmission (Technical Appendix [PDF image 478 KB, 38 pages]); these data were of variable quality and representativeness. For instance, in the case of campylobacteriosis and salmonellosis, underreporting factors based on tourist studies (28,37) have been included in the multipliers, which were higher than underreporting factors from other Western countries for the same pathogens (4,18). Such underreporting factors might not be completely representative of the difference between reported cases resulting in physician visits and cases in the general population because these studies can be subject to several biases (e.g., tourists differ from natives in exposure) (28), although at the same time they cover for phenomena such as undernotification and misdiagnosis of illnesses that were beyond our intention. As a consequence of including data derived by using different method approaches, the plausible range of these multipliers was wide, which resulted in DALY estimates with similarly wide credible intervals (Figure 2). However, despite this limitation, our estimates can still be used for risk ranking purposes.
Uncertainty is also an inherent property of incidence data. Specifically, data for reported cases in Greece (and elsewhere) rely on insufficiently detailed codes, there is incomplete or lacking separate surveillance for many foodborne pathogens, and a specific diagnosis is not given for most episodes of enteric illness requiring hospitalization. These factors result in the greater part of reported cases of gastroenteritis being attributed to ill-defined causes. As with other studies of this kind, assumptions had to be made, notably considering the age of death. Although this assumption did not change the 5 major foodborne risks, it had considerable impact on the individual estimates. We also had to assume that serious cases of illness that have been reported because of a specific agent have been diagnosed and coded correctly or notified to the appropriate authorities. This assumption might not always be the case because at least some of these illnesses are expected to be part of the ill-defined illnesses. A correction for misdiagnosis and undernotification cannot be included for the reported illnesses until country specific data are available. Assigning an arbitrary factor as in other studies (3) introduces new uncertainties and, unlike incidence data in the case of DALY, can affect the ranking of foodborne risks. Thus, our estimates are based only on the illnesses that the surveillance system in Greece currently exposes, and the estimates' robustness can only be further improved through improved surveillance.
As for uncertainty resulting from value choices in the DALY formula itself, in the present study no age-weighting or discounting were used because their combined use has been criticized as attributing considerably fewer disease impacts and effects to younger age groups (38), and disability weights were carefully selected. For policy-making purposes, ideally, disability weights should be based on the opinion of the general public because they should reflect preferences of the society being studied (21). Conceivably, use of the DALY metric could help reduce a considerable part of overall uncertainty by accounting for sequelae, which are not normally taken into consideration in studies focusing solely on incidence of foodborne illness yet do constitute a substantial part of the overall effects on a population. In our study, all well-defined sequelae for which information existed in literature were used for DALY calculations, but our findings could be subject to change when new insights become publicly available. For instance, rates of posthospitalization morbidity related to gastrointestinal illnesses have not been taken into account in the absence of a specific study, although the duration of illness can be longer than the actual hospital stay.
Finally, selection of life tables is another factor that can influence the DALY estimates. When our estimates could be based on West Level 26 life tables, total burden of illness expressed as DALY increased by only 0.0042%, although individual estimates for illnesses could differ by up to 5.0% (results not shown).
Regarding the total incidence of foodborne illnesses, our estimates were in the same range as the estimates for Australia (Table 6), although somewhat higher because the study by Hall et al. was restricted to gastroenteritis-related foodborne illnesses (17). Our estimates of severe reported or estimated cases are between the range of hospitalization rates mentioned for different countries, and the same is the case for our case-fatality rates. Our DALY estimates were higher than estimates for the Netherlands (7) or New Zealand (39), although our estimated overall impact for gastrointestinal illnesses is still comparable to the one from the Netherlands where brucellosis is not a major foodborne risk.
Our finding that brucellosis, salmonellosis, echinococcosis, and toxoplasmosis together accounted for ≈70% of annual DALY means that these diseases might be major targets for policy making regarding appropriate food safety management actions, especially because their causative agents and likely transmission routes are generally known. Overall, the approach may be of interest to competent authorities in other countries requiring risk-based estimates ranking the impact of foodborne pathogens on public health to prioritize risk management actions.


We thank Unilever for sponsoring this research, and the Hellenic Statistical Authority and the Hellenic Center of Infectious Diseases Control for providing us with data necessary for the completion of this study.
Ms Gkogka is a PhD student in the Laboratory of Food Microbiology of Wageningen University. She is interested in food safety management, risks caused by foodborne illnesses, and approaches for assessing risk-based decision making.


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Figure 1. Working scheme for estimating the incidence and effects of foodborne illness in Greece...
Figure 2. Disability-adjusted life years (DALY) caused by different foodborne diseases per million inhabitants in the course of an average year in Greece, including uncertainty...
Figure 3. Trends for the top 5 contributors to the burden of foodborne diseases in Greece, 1996–2006. DALY, disability-adjusted life years.


Table 1. Parameters of the PERT distributions used to describe foodborne transmission, underreporting, and case-fatality rate for foodborne illnesses, Greece, 1996–2006
Table 2. Disability weights related to the diseases included in study of the effects of foodborne infections, Greece, 1996–2006
Table 3. Mean estimated incidence of total foodborne illnesses, reported/estimated illnesses, and deaths attributed to food in Greece per 1 million inhabitants, 1996–2006
Table 4. Estimates of YLL, YLD, and DALY caused by foodborne illnesses in an average year in Greece per 1 million inhabitants, including plausible range attributable to uncertainty
Table 5. Ranking of the top 5 causes contributing to the effects of foodborne illness in Greece as estimated on the basis of individual incidence parameters and disability-adjusted life years, 1996–2006
Table 6. Comparison of foodborne illness effects on public health in Greece with estimates from other countries

Suggested Citation for this Article

Gkogka E, Reij MW, Havelaar AH, Zwietering MH, Gorris LGM. Risk-based estimate of effect of foodborne diseases on public health, Greece. Emerg Infect Dis [serial on the Internet]. 2011 Sep [date cited].

Comments to the Authors
Please use the form below to submit correspondence to the authors or contact them at the following address:
Elissavet Gkogka, Laboratory of Food Microbiology, Wageningen University, PO Box 8129, 6700 EV Wageningen, the Netherlands; email:

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