Genomics|Update|Current: CANCER

Genomics|Update|Current

Cancer

Accuracy of recall of information about a cancer-predisposing BRCA1/2 gene mutation among patients and relatives. 
Chris Jacobs, et al. Eur J Hum Genet, May 21, 2014

Comparison of risk management strategies between women testing positive for a BRCA variant of unknown significance and women with known BRCA deleterious mutations. 
Christine Garcia et al. Genetics in Medicine, May 22, 2014

KRAS mutations and M2PK upregulation in stool samples from individuals with positive fecal occult blood tests screened for colorectal cancer 
Battaglia P, et al. Tumori 2014 Mar-2014 Apr;100(2):122-7

Multi-marker solid tumor panels using next-generation sequencing to direct molecularly targeted therapies
Michael Marrone, Kelly K Filipski, Elizabeth M Gillanders, Sheri D Schully, Andrew N Freedman PLoS Currents Evidence on Genomic Tests 2014 May 27

NCCN increases the emphasis on genetic/familial high-risk assessment in colorectal cancer.
Hampel H. J Natl Compr Canc Netw. 2014 May;12(5 Suppl):829-31.

Predictive and prognostic value of the 21-gene recurrence score in hormone receptor-positive, node-positive breast cancer 
Brufsky AM Am J Clin Oncol 2014 May

Risk estimations and treatment decisions in early stage breast cancer: agreement among oncologists and the impact of the 70-gene signature 
Drukker CA, et al. Eur J Cancer 2014 Apr;50(6):1045-54

Therapy: This time it's personal
Gravitz L Nature 509, S52-S54 2014 May 29