Familial Hypercholesterolemia: Call to Action and Recent Insights

Genomics|Update|2014 December18

Familial Hypercholesterolemia: Call to Action and Recent Insights

CDC paper: Reducing the burden of disease and death from familial hypercholesterolemia: A call to action.
Knowles JW, et al  Am Heart J. 2014 Dec;168(6):807-11

Proceedings of the FH Foundation's inaugural Familial Hypercholesterolemia Summit: Awareness to Action,the FH Foundation (2014)

A framework for bridging the gap in the care of familial hypercholesterolaemia in the community: pragmatic and economic perspectives.
Purchase S, et al Int J Evid Based Healthc. 2014 Dec

Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992-2010. 
Mundal L, et al J Am Heart Assoc. 2014 Dec 2;3(6).

Familial hypercholesterolemia in Brazil: Cascade screening program, clinical and genetic aspects.
Jannes CE, et al. Atherosclerosis. 2014 Nov 14;238(1):101-107

Canadian Cardiovascular Society position statement on familial hypercholesterolemia.
Genest J, et al.  Can J Cardiol. 2014 Dec;30(12):1471-81

Recommendations for the management of patients with familial hypercholesterolemia.
Feldman DI, et al. Curr Atheroscler Rep. 2015 Jan;17(1):473

Systematic detection of familial hypercholesterolaemia in primary health care: A community based prospective study of three methods.
Kirke AB, et al. Heart Lung Circ. 2014 Sep 30

Prevalence and clinical correlates of familial hypercholesterolemia founder mutations in the general population.
Lahtinen AM, et al. Atherosclerosis. 2014 Nov 18;238(1):64-69

Therapy: PCSK9 inhibitors for treating familial hypercholesterolaemia.
Mabuchi H, Nohara A. Nat Rev Endocrinol. 2014 Nov 18

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction.
Nature. 2014 Dec 10 

Molecular basis for familial hypercholesterolemia, Brown and Goldstein Video (Sept 2014) 

Check out our Familial Hypercholesterolemia update page for additional information and links