Cancer Genomics and Precision Medicine
Cancer Precision Medicine: Improving Evidence in Practice - August 21, 2015
NCI-MATCH launch highlights new trial design in precision-medicine era
McNeal C , JNCI, August 2015
McNeal C , JNCI, August 2015
The Cancer Genomics Resource List, 2014
Zutter MM et al. CAP Lab Improvement Program, Archives of Pathology, August 2015
Zutter MM et al. CAP Lab Improvement Program, Archives of Pathology, August 2015
Personalized medicine and economic evaluation in oncology: all theory and no practice?
Garattini L et al. Expert Rev Pharmacoecon Outcomes Res 2015 Aug 9. 1-6
Garattini L et al. Expert Rev Pharmacoecon Outcomes Res 2015 Aug 9. 1-6
Precision medicine trials bring targeted treatments to more patients, C. Helwick, ASCO Post, Jul 25
Next-generation sequencing to guide cancer therapy
Gagan J et al, Genome Medicine, July 29, 2015
Gagan J et al, Genome Medicine, July 29, 2015
Feasibility of large-scale genomic testing to facilitate enrollment onto genomically matched clinical trials.
Meric-Bernstam F et al. J. Clin. Oncol. 2015 May 26.
Meric-Bernstam F et al. J. Clin. Oncol. 2015 May 26.
Brave-ish new world-what's needed to make precision oncology a practical reality.
MacConaill LE et al. JAMA Oncol 2015 Jul 16.
MacConaill LE et al. JAMA Oncol 2015 Jul 16.
Genomic profiling: Building a continuum from knowledge to care
Helen C et al. JAMA Oncology, July 2015
Helen C et al. JAMA Oncology, July 2015
Are we there yet?
When it comes to curing cancer, targeted therapies and genomic sequencing are helping, but we still have far to go. Genome Magazine, June 29, 2015
When it comes to curing cancer, targeted therapies and genomic sequencing are helping, but we still have far to go. Genome Magazine, June 29, 2015
Artificial intelligence, big data, and cancer
Kantarjian H et al, JAMA Oncology, June 2015
Kantarjian H et al, JAMA Oncology, June 2015
Multigene panel testing in oncology practice - how should we respond?
Kurian AW et al. JAMA Oncology, June 2015
Kurian AW et al. JAMA Oncology, June 2015
Use of whole genome sequencing for diagnosis and discovery in the cancer genetics clinic.
Foley SB et al. EBioMedicine 2015 Jan 2(1) 74-81
Foley SB et al. EBioMedicine 2015 Jan 2(1) 74-81
The future of molecular medicine: biomarkers, BATTLEs, and big data
ES Kim, ASCO University, June 2015
ES Kim, ASCO University, June 2015
Targeted agent and profiling utilization registry study, from the American Society for Clinical Oncology
ASCO study aims to learn from patient access to targeted cancer drugs used off-label, American Society for Clinical Oncology
Improving evidence developed from population-level experience with targeted agents [PDF 462.93 KB]
McLellan M et al Issue Brief. Conference on Clinical Cancer Research November 2014
McLellan M et al Issue Brief. Conference on Clinical Cancer Research November 2014
Implementing personalized cancer care.
Schilsky RL et al. Nat Rev Clin Oncol 2014 Jul (7) 432-8
Schilsky RL et al. Nat Rev Clin Oncol 2014 Jul (7) 432-8
Accelerating the delivery of patient-centered, high-quality cancer care.
Abrahams E et al. Clin. Cancer Res. 2015 May 15. (10) 2263-7
Abrahams E et al. Clin. Cancer Res. 2015 May 15. (10) 2263-7
Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity.
Catenacci DV et al. Mol Oncol 2015 May (5) 967-996
Catenacci DV et al. Mol Oncol 2015 May (5) 967-996
Cancer Precision Medicine: Improving Evidence in Practice - May 29, 2015
Diagnosis and treatment of cancer using genomics
Vockley JG et al. BMJ, May 28, 2015
Vockley JG et al. BMJ, May 28, 2015
Targeted agent and profiling utilization registry study, from the American Society for Clinical Oncology
ASCO study aims to learn from patient access to targeted cancer drugs used off-label, American Society for Clinical Oncology
Improving evidence developed from population-level experience with targeted agents [PDF 462.93 KB]
McLellan M et al Issue Brief. Conference on Clinical Cancer Research November 2014
McLellan M et al Issue Brief. Conference on Clinical Cancer Research November 2014
Implementing personalized cancer care.
Schilsky RL et al. Nat Rev Clin Oncol 2014 Jul (7) 432-8
Schilsky RL et al. Nat Rev Clin Oncol 2014 Jul (7) 432-8
Accelerating the delivery of patient-centered, high-quality cancer care.
Abrahams E et al. Clin. Cancer Res. 2015 May 15. (10) 2263-7
Abrahams E et al. Clin. Cancer Res. 2015 May 15. (10) 2263-7
Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity.
Catenacci DV et al. Mol Oncol 2015 May (5) 967-996
Catenacci DV et al. Mol Oncol 2015 May (5) 967-996
Precision Medicine: Cancer and Genomics - May 12, 2015
Promise, peril seen in personalized cancer therapy, by Marie McCullough, Philadelphia Inquirer, May 10
A decision support framework for genomically informed investigational cancer therapy.
Meric-Bernstam F et al. J. Natl. Cancer Inst. 2015 Jul (7)
Meric-Bernstam F et al. J. Natl. Cancer Inst. 2015 Jul (7)
Divide and conquer: The molecular diagnosis of cancer, by Louis M. Staudt, National Cancer Insitute, Apr 13
Health: Make precision medicine work for cancer care
To get targeted treatments to more cancer patients pair genomic data with clinical data, and make the information widely accessible, Mark A. Rubin. Nature News, Apr 15
To get targeted treatments to more cancer patients pair genomic data with clinical data, and make the information widely accessible, Mark A. Rubin. Nature News, Apr 15
Using somatic mutations to guide treatment decisions
Horlings H et al. JAMA Oncology, March 12, 2015
Horlings H et al. JAMA Oncology, March 12, 2015
The landscape of precision cancer medicine clinical trials in the United States
Roper N et al. Cancer Treatment Reviews 2015
Roper N et al. Cancer Treatment Reviews 2015
What is “precision medicine? Information from the National Cancer Institute
Impact of cancer genomics on precision medicine for the treatment of cancer, from the Cancer Genome Atlas, NCI
US precision-medicine proposal sparks questions, by Sara Reardon, Nature News, Jan 22
Obama's 'precision medicine' means gene mapping, NBC News, Jan 21
What is President Obama's 'precision medicine' plan, and how might it help you? By Lenny Bernstein, Jan 21
Recent reviews
Companion diagnostics: the key to personalized medicine.
Jørgensen JT. Expert Rev Mol Diagn. 2015 Feb;15(2):153-6
Jørgensen JT. Expert Rev Mol Diagn. 2015 Feb;15(2):153-6
Promoting precision cancer medicine through a community-driven knowledgebase.
Geifman N, et al. J Pers Med. 2014 Dec 15;4(4):475-88.
Geifman N, et al. J Pers Med. 2014 Dec 15;4(4):475-88.
Toward a prostate cancer precision medicine.
Rubin MA. Urol Oncol. 2014 Nov 20.
Rubin MA. Urol Oncol. 2014 Nov 20.
Prioritizing targets for precision cancer medicine.
Andre F, et al. Ann Oncol. 2014 Dec;25(12):2295-303
Andre F, et al. Ann Oncol. 2014 Dec;25(12):2295-303
Toward precision medicine with next-generation EGFR inhibitors in non-small-cell lung cancer.
Yap TA, Popat S. Pharmgenomics Pers Med. 2014 Sep 19;7:285-95.
Yap TA, Popat S. Pharmgenomics Pers Med. 2014 Sep 19;7:285-95.
Genomically driven precision medicine to improve outcomes in anaplastic thyroid cancer.
Pinto N, et al. J Oncol. 2014;936285
Pinto N, et al. J Oncol. 2014;936285
Translating genomics for precision cancer medicine.
Roychowdhury S, Chinnaiyan AM. Annu Rev Genomics Hum Genet. 2014;15:395-415
Roychowdhury S, Chinnaiyan AM. Annu Rev Genomics Hum Genet. 2014;15:395-415
The Cancer Genome Atlas: Accomplishments and Future - April 3, 2015
The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge
Tomczak K, et al. Contemp Oncol (Pozn). 2015; 19(1A): A68-A77.
Tomczak K, et al. Contemp Oncol (Pozn). 2015; 19(1A): A68-A77.
The Cancer Genome Atlas' 4th Annual Scientific Symposium
May 11-12 ~ Bethesda, MD
May 11-12 ~ Bethesda, MD
The Cancer Genome Atlas (TCGA) Data Portal
Portal provides a platform for researchers to search, download, and analyze data sets generated by TCGA
Portal provides a platform for researchers to search, download, and analyze data sets generated by TCGA
Cancer Genomics Hub: A resource of the National Cancer Institute, from the USC Genome Browser
Molecular classification of gastric adenocarcinoma: translating new insights from The Cancer Genome Atlas Research Network.
Sunakawa Y et al. Curr Treat Options Oncol 2015 Apr (4) 331
Sunakawa Y et al. Curr Treat Options Oncol 2015 Apr (4) 331
TCGA data and patient-derived orthotopic xenografts highlight pancreatic cancer-associated angiogenesis.
Gore J et al. Oncotarget 2015 Feb 25.
Gore J et al. Oncotarget 2015 Feb 25.
Radiogenomics of clear cell renal cell carcinoma: preliminary findings of The Cancer Genome Atlas-Renal Cell Carcinoma (TCGA-RCC) Imaging Research Group.
Shinagare AB et al. Abdom Imaging 2015 Mar 10.
Shinagare AB et al. Abdom Imaging 2015 Mar 10.
Proteomics of colorectal cancer in a genomic context: First large-scale mass spectrometry-based analysis from the Cancer Genome Atlas.
Jimenez CR et al. Clin. Chem. 2015 Feb 26.
Jimenez CR et al. Clin. Chem. 2015 Feb 26.
End of cancer-genome project prompts rethink
Geneticists debate whether focus should shift from sequencing genomes to analysing function. Heidi Ledford, Nature News and Comments, January 2015
Geneticists debate whether focus should shift from sequencing genomes to analysing function. Heidi Ledford, Nature News and Comments, January 2015
Cancer Genomics: Insights into Driver Mutations - March 10, 2015
Seek and destroy: Relating cancer drivers to therapies
E. Martinez-Ledesma et al. Cell, March 9, 2015
E. Martinez-Ledesma et al. Cell, March 9, 2015
In silico prescription of anticancer drugs to cohorts of 28 tumor types reveals targeting opportunities
C Rubio-Perez et al. Cancer Cell, March 9, 2015
C Rubio-Perez et al. Cancer Cell, March 9, 2015
MADGiC: a model-based approach for identifying driver genes in cancer. [PDF 373.56 KB]
Keegan D. Korthauer et al. Bioinformatics, January 2015
Keegan D. Korthauer et al. Bioinformatics, January 2015
Identifying driver mutations in sequenced cancer genomes: computational approaches to enable precision medicine.
Benjamin J Raphael et al. Genome Medicine 2014
Benjamin J Raphael et al. Genome Medicine 2014
Novel recurrently mutated genes in African American colon cancers.
Guda K et al. Proc Natl Acad Sci U S A. 2015 Jan 12
Guda K et al. Proc Natl Acad Sci U S A. 2015 Jan 12
Sparse expression bases in cancer reveal tumor drivers.
Logsdon BA, et al. Nucleic Acids Res. 2015 Jan 12
Logsdon BA, et al. Nucleic Acids Res. 2015 Jan 12
Patient-specific driver gene prediction and risk assessment through integrated network analysis of cancer omics profiles.
Bertrand D, et al. Nucleic Acids Res. 2015 Jan 8
Bertrand D, et al. Nucleic Acids Res. 2015 Jan 8
Identification of constrained cancer driver genes based on mutation timing.
Sakoparnig T, et al. PLoS Comput Biol. 2015 Jan 8;11(1):e1004027
Sakoparnig T, et al. PLoS Comput Biol. 2015 Jan 8;11(1):e1004027
CaMoDi: a new method for cancer module discovery.
Manolakos A, et al. BMC Genomics. 2014 Dec 12;15 Suppl 10:S8.
Manolakos A, et al. BMC Genomics. 2014 Dec 12;15 Suppl 10:S8.
VHL, the story of a tumour suppressor gene.
Gossage L, et al. Nat Rev Cancer. 2014 Dec 23;15(1):55-64
Gossage L, et al. Nat Rev Cancer. 2014 Dec 23;15(1):55-64
Targeting the MET pathway for potential treatment of NSCLC.
Li A, et al. Expert Opin Ther Targets. 2014 Dec 23:1-12
Li A, et al. Expert Opin Ther Targets. 2014 Dec 23:1-12
Deciphering oncogenic drivers: from single genes to integrated pathways.
Chen J, et al. Brief Bioinform. 2014 Nov 5.
Chen J, et al. Brief Bioinform. 2014 Nov 5.
Driver and passenger mutations in cancer.
Pon JR, et al. Annu Rev Pathol. 2014 Oct 17
Pon JR, et al. Annu Rev Pathol. 2014 Oct 17
Hereditary Cancer Genetic Testing: Where are We? - December 18, 2014
NCI paper: Prevalence and correlates of receiving and sharing high-penetrance cancer genetic test results: Findings from the Health Information National Trends Survey
Taber J.M. et al Public Health Genomics, January 2015
Taber J.M. et al Public Health Genomics, January 2015
Clinical decisions: Screening an asymptomatic person for genetic risk--polling results
Schulte J, et al. N Engl J Med 2014 Nov;371(20):e30
Schulte J, et al. N Engl J Med 2014 Nov;371(20):e30
Testing for hereditary breast cancer: Panel or targeted testing? Experience from a clinical cancer genetics practice.
Doherty J, J Genet Couns. 2014 Dec 5
Doherty J, J Genet Couns. 2014 Dec 5
Hereditary colorectal cancer syndromes: American Society of Clinical Oncology clinical practice guideline endorsement of the familial risk-colorectal cancer: European Society for Medical Oncology clinical practice guidelines.
Stoffel EM, et al. J Clin Oncol. 2014 Dec 1
Stoffel EM, et al. J Clin Oncol. 2014 Dec 1
Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: A randomized controlled trial.
Manchanda R, et al. J Natl Cancer Inst. 2014 Nov 30;107(1)
Manchanda R, et al. J Natl Cancer Inst. 2014 Nov 30;107(1)
Cost-effectiveness of population screening for BRCA mutations in Ashkenazi Jewish women compared with family history-based testing.
Manchanda R et al. J Natl Cancer Inst. 2014 Nov 30;107(1). pii: dju380. doi: 10.1093/jnci/dju380. Print 2015 Jan.
Manchanda R et al. J Natl Cancer Inst. 2014 Nov 30;107(1). pii: dju380. doi: 10.1093/jnci/dju380. Print 2015 Jan.
Check out our Cancer Genetic Testing Update Page for additional information and links
Cancer Genomic Tests (October 30, 2014)
Cancer Genomic Tests: Accelerating Translation - October 30, 2014
CDC-NCI paper: An overview of recommendations and translational milestones for genomic tests in cancer
Christine Q. Chang et al. Genetics in Medicine, October 22, 2014
Christine Q. Chang et al. Genetics in Medicine, October 22, 2014
Check out the NCI Cancer Genomics and Epidemiology Navigator for latest information on cancer genomic tests
EGAPP: A model process for evaluating genomic applications in practice and prevention. Check out cancer genomic tests, methods, evidence reviews and recommendation statements.
NCI Fact Sheet: Genetic testing for hereditary cancer syndromes
Cancer Genomics: Impact of Recent Insights - October 30, 2014
Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin.
Katherine A. Hoadley et al. Cell, August 2014
Katherine A. Hoadley et al. Cell, August 2014
Genome study overhauls cancer categories, shifts from tissues to molecular subtypes, by Kevin Mayer, Genetics Bioengineering News, Aug 8
It's time for us to think about cancer differently, by Paula Mejia, Newsweek, Aug 8
NIH information: What is cancer genomics and the genetic basis of cancer?
Cancer Precision Medicine: Where Are We? - September 18, 2014
NIH announces the launch of 3 integrated precision medicine trials; ALCHEMIST is for patients with certain types of early-stage lung cancer, August 2014
National Cancer Institute's Precision Medicine Initiatives for the New National Clinical Trials Network.Jeffrey Abrams et al. ASCO Annual Meeting 2014
Personalized medicine: Special treatment.
Michael Eisenstein. Nature, September 11, 2014
Michael Eisenstein. Nature, September 11, 2014
Why the controversy? Start sequencing tumor genes at diagnosis. Tumor sequencing at the time of diagnosis can give significant insight for successful cancer treatment, by Shelly Gunn, Genetic Engineering & Biotechnology News, Sep 10
National Cancer Institute information: Precision medicine and targeted therapy
Genomics and precision oncology: What's a targeted therapy for cancer? An updated list of approved drugs from the National Cancer Institute (2014)
Therapy: This time it's personal
Gravitz L Nature 509, S52-S54 2014 May 29
Gravitz L Nature 509, S52-S54 2014 May 29
Multi-marker solid tumor panels using next-generation sequencing to direct molecularly targeted therapies
Michael Marrone, et al. PLoS Currents Evidence on Genomic Tests 2014 May 27
Michael Marrone, et al. PLoS Currents Evidence on Genomic Tests 2014 May 27
Impact of cancer genomics on precision medicine for the treatment of cancer, from the National Cancer Institute
Cancer genomics and precision medicine in the 21st century [PDF 2.20 MB], power point presentation from the National Human Genome Research Institute
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