Medical Genome Sequencing: Evidence and Ethics

Genomics|Update|Current

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Medical Genome Sequencing: Evidence and Ethics

• ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing  [PDF 342.83 KB]
  Robert C. Green, Jonathan S. Berg, Wayne W. Grody, et al. ACMG
• ACMG clarifies statements on return of incidental findings  [PDF 132.05 KB]
• CDC blog post: On spinning wheels and genomes revealed: Sequencing is no longer a sleeping controversy
• EGAPP approach to classification of incidental findings: Description and pilot results from a novel method for evaluating return of incidental findings from next-generation sequencing technologies.  [PDF 656.44 KB]
  Katrina A.B. Goddard et al. Genetics in Medicine May 2013
• Ethics and genomic incidental findings: Laboratories have an obligation to report clinically beneficial incidental findings.
  Amy L. McGuire et al. Science May 16
• Patient autonomy and incidental findings in clinical genomics: Returning genetic incidental findings without patient consent is misguided.
  Susan M. Wolf et al. Science May 16
• Genetic testing guidelines under fire, By Rachael Rettner, Fox News, May 20
• Debate heats up on ACMG's incidental findings recommendations, Genome Web, May 20 [by free subscription only]
  
• ACMG guidelines on IFs – responding to the response…, Genomes Unzipped, May 16