A primer on precision medicine informatics. - PubMed - NCBI

A primer on precision medicine informatics. - PubMed - NCBI

Brief Bioinform. 2016 Jan;17(1):145-53. doi: 10.1093/bib/bbv032. Epub 2015 Jun 5.

A primer on precision medicine informatics.

Sboner A, Elemento O.

Abstract

In this review, we describe key components of a computational infrastructure for a precision medicine program that is based on clinical-grade genomic sequencing. Specific aspects covered in this review include software components and hardware infrastructure, reporting, integration into Electronic Health Records for routine clinical use and regulatory aspects. We emphasize informatics components related to reproducibility and reliability in genomic testing, regulatory compliance, traceability and documentation of processes, integration into clinical workflows, privacy requirements, prioritization and interpretation of results to report based on clinical needs, rapidly evolving knowledge base of genomic alterations and clinical treatments and return of results in a timely and predictable fashion. We also seek to differentiate between the use of precision medicine in germline and cancer.

© The Author 2015. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.

KEYWORDS:

NGS testing; clinical genomics; computational biology; informatics; precision medicine

PMID:

 

26048401

 

DOI:

 

10.1093/bib/bbv032

[PubMed - indexed for MEDLINE]

Public Health Genomics Knowledge Base (v1.2)

Last Posted: Nov-04-2016 2PM

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