Statewide Colon Cancer Initiative
The Ohio Colorectal Cancer Prevention Initiative (OCCPI), led by Heather Hampel, MS, CGC, is a statewide initiative to screen newly diagnosed colorectal cancer (CRC) patients and their biological relatives for Lynch syndrome, a cancer-causing condition that occurs when a person inherits a mutation in one of four genes. Individuals with Lynch syndrome are very likely to develop CRC, uterine, ovarian, stomach or other cancers during their lifetime. The screening effort – made possible through money raised by Pelotonia – will identify family members who may be at risk of developing these cancers so they can take precautionary measures.
Approximately 3 percent of colorectal cancer cases result from Lynch syndrome. Each CRC patient with Lynch syndrome has, on average, three relatives with the syndrome, heightening their risk for CRC and other cancers.
Based in large part on research conducted at the OSUCCC – James from 1999-2008, the Centers for Disease Control’s Evaluation of Genomic Applications in Practice and Prevention working group recommends that all newly diagnosed CRC patients be screened for Lynch syndrome. The OSUCCC – James has done this since 2006 to help reduce morbidity and mortality in colorectal cancer patients and their at-risk relatives, who can also benefit from increased surveillance methods if they too are found to have Lynch syndrome.
The OCCPI includes 50 hospitals throughout Ohio that will implement the Lynch syndrome screening program at their own institutions. They will advise patients and their physicians of the results, offer genetic counseling and make high-risk cancer surveillance recommendations to patients and family members found to have Lynch syndrome.
It is estimated that the OCCPI will save about 639 years of life among Ohioans.
And to prevent ovarian and uterine cancers, women with Lynch syndrome may choose to have a hysterectomy, including removal of their ovaries, once they are finished having children.
More Information
To learn more about study enrollment, call 1-888-329-1654.
Public Health Genomics Knowledge Base (v1.2)
LYNCH SYNDROME
Last Updated: Nov 15, 2016
- Ohio Statewide Colon Cancer Initiative
- Time is running out to get a free cancer screening
R Murray, Dayton Daily News, November 14, 2016 - Cost-effectiveness of routine screening for Lynch syndrome in endometrial cancer patients up to 70years of age.
Goverde Anne et al. Gynecologic oncology 2016 Oct - Germline multi-gene hereditary cancer panel testing in an unselected endometrial cancer cohort.
Ring Kari L, et al. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2016 11 (11) 1381-1389 - Prevalence of Lynch syndrome in unselected patients with endometrial or ovarian cancer.
Kast Karin, et al. Archives of gynecology and obstetrics 2016 11 (6) 1299-1303 - NICE recommends all bowel cancer patients to be tested for Lynch Syndrome
Bowel Cancer UK, October 22, 2016 - NICE recommends wider use of tests to detect cancer-causing genetic condition
NICE, United Kingdom, Draft Guidance, October 21, 2016 - Educational and Psychosocial Support Needs in Lynch Syndrome: Implementation and Assessment of an Educational Workshop and Support Group.
Corines Marina J et al. Journal of genetic counseling 2016 Oct - Implementing Public Health Genomics in Your State: Resources from the CDC Office of Public Health Genomics
Disease: Lynch syndrome|Breast Cancer|Ovarian Cancer; Type: Education; State: Multiple States - Evaluation of a Population Based Approach to Familial Colorectal Cancer.
Parfrey P S, et al. Clinical genetics 2016 10 - Exploring clinicians' attitudes about using aspirin for risk reduction in people with Lynch Syndrome with no personal diagnosis of colorectal cancer.
Chen Yanni et al. Familial cancer 2016 Sep - Genetic screening in young women diagnosed with endometrial cancer.
Pecorino Basilio et al. Journal of gynecologic oncology 2016 Sep e4 - Endometrial carcinoma-related genetic factors: application to research and clinical practice in China.
Zhou J Y, et al. BJOG : an international journal of obstetrics and gynaecology 2016 9 90-6 - MLH1 Ile219Val Polymorphism in Argentinean Families with Suspected Lynch Syndrome.
Dominguez-Valentin Mev, et al. Frontiers in oncology 2016 0 189 - Mismatch repair gene mutation spectrum in the Swedish Lynch syndrome population.
Lagerstedt-Robinson Kristina, et al. Oncology reports 2016 9
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